PDGF-AB（血小(xiao)板衍生(sheng)(sheng)(sheng)生(sheng)(sheng)(sheng)長因(yin)(yin)子-AB）是一(yi)種重(zhong)要的二(er)聚體(ti)蛋白生(sheng)(sheng)(sheng)長因(yin)(yin)子，屬(shu)(shu)于PDGF家(jia)族，由(you)A鏈(lian)(lian)和B鏈(lian)(lian)通過(guo)二(er)硫鍵(jian)連接而(er)成。它(ta)主(zhu)要由(you)血小(xiao)板、內(nei)皮(pi)細(xi)胞(bao)(bao)(bao)(bao)、巨(ju)噬細(xi)胞(bao)(bao)(bao)(bao)等分(fen)泌，在(zai)間充質干細(xi)胞(bao)(bao)(bao)(bao)（MSCs）培養中，PDGF-AB可促進其(qi)(qi)增(zeng)殖并維持多向分(fen)化潛能(neng)。它(ta)能(neng)抑(yi)制(zhi)凋亡途徑，增(zeng)強(qiang)細(xi)胞(bao)(bao)(bao)(bao)存活能(neng)力(li)，尤(you)其(qi)(qi)在(zai)低血清或(huo)無血清培養條件下尤(you)為重(zhong)要。在(zai)組(zu)織修復、胚胎發育和細(xi)胞(bao)(bao)(bao)(bao)增(zeng)殖中起關(guan)鍵(jian)作用(yong)。北京科(ke)昕(xin)生(sheng)(sheng)(sheng)物科(ke)技有(you)限生(sheng)(sheng)(sheng)產(chan)的PDGF-AB表(biao)達系(xi)統為CHO，通過(guo)SDS-PAGE測定純度≥95%，內(nei)毒素通過(guo)LAL方法測定≤10EU/mg。采用(yong)NIH3T3細(xi)胞(bao)(bao)(bao)(bao)的細(xi)胞(bao)(bao)(bao)(bao)增(zeng)殖實驗檢(jian)測其(qi)(qi)生(sheng)(sheng)(sheng)物活性，其(qi)(qi)ED50≤1.0ng/ml。該公司依托優良的檢(jian)測技術，可對(dui)產(chan)品質量進行檢(jian)測，確保符合GMP標準與企業使用(yong)要求(qiu)。IL-21（白細(xi)胞(bao)(bao)(bao)(bao)介素-21）是一(yi)種多效性細(xi)胞(bao)(bao)(bao)(bao)因(yin)(yin)子，屬(shu)(shu)于γc（共同(tong)γ鏈(lian)(lian)）細(xi)胞(bao)(bao)(bao)(bao)因(yin)(yin)子家(jia)族。河(he)南(nan)VEGF生(sheng)(sheng)(sheng)長因(yin)(yin)子有(you)什(shen)么(me)作用(yong)

IL-6（白細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)介素(su)(su)-6）是一種多效性細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)因(yin)子，由多種細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)（如(ru)T細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、B細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、巨噬(shi)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、成(cheng)纖維細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、內(nei)皮細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)等）分(fen)泌(mi)，在免(mian)疫(yi)調(diao)節、炎癥(zheng)反(fan)應、造(zao)血、代(dai)謝及組(zu)織(zhi)修復中發揮關鍵作用。其(qi)信(xin)號(hao)通過gp130和(he)IL-6受體（IL-6R）組(zu)成(cheng)的復合物傳(chuan)遞，激(ji)活JAK/STAT、MAPK和(he)PI3K等信(xin)號(hao)通路。IL-6在免(mian)疫(yi)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)（如(ru)T細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、B細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)、巨噬(shi)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)）培養中促(cu)進Th17細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)分(fen)化(hua)（與自身免(mian)疫(yi)相關），抑制Treg細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)功(gong)能，并(bing)刺(ci)激(ji)B細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)分(fen)化(hua)為(wei)漿細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)，增(zeng)強抗(kang)體產生；在造(zao)血干細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)培養中，IL-6與其(qi)他細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)因(yin)子（如(ru)IL-3、SCF）協同作用，促(cu)進造(zao)血祖(zu)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)的增(zeng)殖(zhi)和(he)分(fen)化(hua)，尤其(qi)是巨核細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)和(he)粒(li)細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)系(xi)(xi)。北京科昕生物科技有限(xian)公(gong)(gong)(gong)司生產的IL-6表(biao)達系(xi)(xi)統為(wei)CHO，純度≥95%，通過SDS-PAGE測(ce)定。內(nei)毒素(su)(su)≤10EU/mg，通過LAL方法測(ce)定。使用M-NFS-60細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)的細(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)增(zeng)殖(zhi)實驗測(ce)量IL-6生物活性，該效應的ED50為(wei)0.2-1ng/mL。該公(gong)(gong)(gong)司可(ke)提供清晰的采購流程，如(ru)客戶(hu)確認需求(qiu)并(bing)簽訂合同后可(ke)安排立即(ji)發貨(huo)，幫助(zhu)企業順利(li)開展工(gong)作。四(si)川NK廠家聯系(xi)(xi)方式(shi)生長因(yin)子廠家的聯系(xi)(xi)方式(shi)公(gong)(gong)(gong)開透(tou)明，方便(bian)客戶(hu)進行咨詢(xun)。

PDGF-AA（血小(xiao)板(ban)衍生(sheng)生(sheng)長(chang)因(yin)子-AA）是血小(xiao)板(ban)衍生(sheng)生(sheng)長(chang)因(yin)子（PDGF）家(jia)族的(de)(de)(de)(de)一(yi)種亞型，由兩條相(xiang)同的(de)(de)(de)(de)A鏈組成(cheng)。PDGF家(jia)族是一(yi)類重(zhong)要(yao)的(de)(de)(de)(de)生(sheng)長(chang)因(yin)子，主要(yao)通過激(ji)活(huo)細(xi)(xi)(xi)(xi)胞(bao)膜上的(de)(de)(de)(de)酪(lao)氨酸激(ji)酶(mei)受體(ti)(ti)（PDGFR-αα、PDGFR-αβ或PDGFR-ββ）調控細(xi)(xi)(xi)(xi)胞(bao)增(zeng)(zeng)(zeng)殖(zhi)(zhi)、遷移、分化和存活(huo)等(deng)過程。PDGF-AA特異性(xing)結合PDGFR-αα受體(ti)(ti)，刺(ci)激(ji)特定(ding)(ding)細(xi)(xi)(xi)(xi)胞(bao)（如成(cheng)纖維(wei)細(xi)(xi)(xi)(xi)胞(bao)、神經膠質細(xi)(xi)(xi)(xi)胞(bao)、間(jian)充(chong)質干細(xi)(xi)(xi)(xi)胞(bao)等(deng)）的(de)(de)(de)(de)增(zeng)(zeng)(zeng)殖(zhi)(zhi)，常用于原代細(xi)(xi)(xi)(xi)胞(bao)或難培養細(xi)(xi)(xi)(xi)胞(bao)的(de)(de)(de)(de)擴增(zeng)(zeng)(zeng)；對某(mou)些間(jian)充(chong)質干細(xi)(xi)(xi)(xi)胞(bao)（MSCs）或神經前體(ti)(ti)細(xi)(xi)(xi)(xi)胞(bao)，PDGF-AA可(ke)幫助維(wei)持(chi)其未分化狀態或促(cu)進定(ding)(ding)向分化，如向成(cheng)骨細(xi)(xi)(xi)(xi)胞(bao)或膠質細(xi)(xi)(xi)(xi)胞(bao)分化。北京科昕生(sheng)物(wu)科技有限公司(si)可(ke)針對PDGF-AA提供完善的(de)(de)(de)(de)解決方案，包括(kuo)產(chan)品供應、保存指導及(ji)應用支(zhi)持(chi)，滿足企業生(sheng)產(chan)場(chang)景的(de)(de)(de)(de)使用需求(qiu)。該(gai)公司(si)生(sheng)產(chan)的(de)(de)(de)(de)PDGF-AA表達系統為CHO，通過SDS-PAGE測(ce)定(ding)(ding)純度≥95%，內毒素(su)通過LAL方法測(ce)定(ding)(ding)≤10EU/mg。該(gai)活(huo)性(xing)通過NIH3T3細(xi)(xi)(xi)(xi)胞(bao)的(de)(de)(de)(de)劑量依(yi)賴性(xing)增(zeng)(zeng)(zeng)殖(zhi)(zhi)實驗來確(que)定(ding)(ding)，ED50通常≤5.0ng/mL。

尋找價格較低的(de)(de)(de)FGF-10的(de)(de)(de)企業可(ke)關注北京科(ke)昕(xin)生(sheng)物科(ke)技有限(xian)公(gong)司，其通(tong)過工(gong)藝優化(hua)與規(gui)模制備降(jiang)低成本，在保障(zhang)GMP級質量(liang)的(de)(de)(de)同時提供性價比(bi)較高的(de)(de)(de)產(chan)品。FGF-10（成纖(xian)維細胞(bao)生(sheng)長因(yin)子-10）屬(shu)于(yu)FGF家族成員(yuan),是一種(zhong)分泌(mi)型(xing)蛋白(bai)，與FGF-7（KGF）高度同源(yuan)，通(tong)過結合(he)FGFR2b受體發揮作用(yong)。主要參與上(shang)皮-間質相互作用(yong)，調控胚(pei)胎發育(yu)、組織修復和器(qi)官形成（如肺、皮膚、前(qian)列腺等）。FGF-10可(ke)促進上(shang)皮細胞(bao)（如角質形成細胞(bao)、肺泡上(shang)皮細胞(bao)、乳(ru)腺上(shang)皮細胞(bao)）和某些間充質干細胞(bao)（MSCs）的(de)(de)(de)增殖；與Wnt信號通(tong)路協同，用(yong)于(yu)腸道、肺等類器(qi)官的(de)(de)(de)長期(qi)培養。該(gai)(gai)公(gong)司生(sheng)產(chan)的(de)(de)(de)FGF-10表達系統為CHO，通(tong)過SDS-PAGE測定純度≥95%，內毒素通(tong)過LAL方法(fa)測定≤10EU/mg。通(tong)過其誘導人骨(gu)肉瘤Saos-2細胞(bao)系分泌(mi)IL-11的(de)(de)(de)能力進行測定生(sheng)物活(huo)性，該(gai)(gai)效應的(de)(de)(de)ED50≤2μg/mL。M-CSF保存需遵循(xun)特定溫度與濕度要求，防止活(huo)性降(jiang)低影響實驗或生(sheng)產(chan)效果。

企業在購買腦源性(xing)神(shen)經(jing)營(ying)養(yang)(yang)因子(zi)時，會想(xiang)了(le)解如(ru)何(he)保(bao)存(cun)(cun)其(qi)(qi)活性(xing)。腦源性(xing)神(shen)經(jing)營(ying)養(yang)(yang)因子(zi)由真(zhen)核細(xi)(xi)胞表(biao)達的(de)重組蛋(dan)白(bai)，是將(jiang)蛋(dan)白(bai)基因接入穩(wen)定(ding)(ding)(ding)(ding)表(biao)達載體，轉化CHO-K1細(xi)(xi)胞，經(jing)克(ke)隆篩(shai)選(xuan)，質(zhi)(zhi)量(liang)驗證，挑(tiao)選(xuan)的(de)穩(wen)定(ding)(ding)(ding)(ding)表(biao)達株(zhu)，由化學成分確定(ding)(ding)(ding)(ding)的(de)培養(yang)(yang)基（不(bu)含(han)有(you)任何(he)動物(wu)源成分）發酵制備，工(gong)(gong)藝穩(wen)定(ding)(ding)(ding)(ding)，保(bao)證了(le)產(chan)(chan)品(pin)質(zhi)(zhi)量(liang)及批(pi)次間的(de)一(yi)致性(xing)。本產(chan)(chan)品(pin)為無菌凍(dong)(dong)干(gan)粉劑，由含(han)有(you)10mM磷酸鹽pH為7.2的(de)蛋(dan)白(bai)溶液經(jing)0.2μm過(guo)(guo)濾后分裝(zhuang)凍(dong)(dong)干(gan)。建(jian)議將(jiang)凍(dong)(dong)干(gan)rHuBDNF溶解在注射用水(shui)或滅(mie)菌的(de)超純(chun)水(shui)中，濃度不(bu)低(di)于100μg/ml，以待(dai)進(jin)一(yi)步稀釋至工(gong)(gong)作濃度。避免反復凍(dong)(dong)融。復溶后的(de)細(xi)(xi)胞因子(zi)：4℃可穩(wen)定(ding)(ding)(ding)(ding)儲存(cun)(cun)7-10天；長期保(bao)存(cun)(cun)請分裝(zhuang)后存(cun)(cun)放于-20℃。北京(jing)(jing)科(ke)昕生(sheng)(sheng)物(wu)科(ke)技有(you)限公(gong)司(si)的(de)重組人(ren)BDNF，表(biao)達系統(tong)為CHO，純(chun)度≥95%，通(tong)(tong)過(guo)(guo)SDS-PAGE測定(ding)(ding)(ding)(ding)。經(jing)過(guo)(guo)LAL方法測定(ding)(ding)(ding)(ding)的(de)內(nei)毒(du)素含(han)量(liang)≤10EU/mg。BDNF通(tong)(tong)過(guo)(guo)功能ELISA的(de)結(jie)合能力(li)測量(liang)生(sheng)(sheng)物(wu)活性(xing)，固定(ding)(ding)(ding)(ding)的(de)人(ren)類BDNF可以與人(ren)類TrKB結(jie)合。其(qi)(qi)提供腦源性(xing)神(shen)經(jing)營(ying)養(yang)(yang)因子(zi)產(chan)(chan)品(pin)時，會附帶詳細(xi)(xi)的(de)保(bao)存(cun)(cun)操(cao)作指南，結(jie)合其(qi)(qi)GMP級生(sheng)(sheng)產(chan)(chan)質(zhi)(zhi)控，從(cong)源頭降(jiang)低(di)保(bao)存(cun)(cun)環節的(de)質(zhi)(zhi)量(liang)風險(xian)。挑(tiao)選(xuan)BMP-7供應商時，可從(cong)生(sheng)(sheng)產(chan)(chan)資質(zhi)(zhi)、交付能力(li)及售后支持等維度綜合評估推薦。北京(jing)(jing)細(xi)(xi)胞肉細(xi)(xi)胞培養(yang)(yang)蛋(dan)白(bai)

胎球蛋白A主要由肝臟合成(cheng)并分泌(mi)到血液中在多種生(sheng)理(li)和病理(li)過程中發揮作(zuo)用(yong)。河南VEGF生(sheng)長(chang)因子有什么作(zuo)用(yong)

北京科昕生(sheng)(sheng)(sheng)物(wu)科技有(you)限公司可(ke)(ke)提供多種(zhong)細胞(bao)因(yin)(yin)子產(chan)(chan)品，包(bao)括Activin A、BDNF、LR3IGF-1、R-Spondin-1等，生(sheng)(sheng)(sheng)產(chan)(chan)依托GMP級設施與(yu)成(cheng)熟工藝。其(qi)(qi)中，R-Spondin-1（RSPO1）是一種(zhong)分泌型蛋白(bai)，屬于R-Spondin蛋白(bai)家族。它通(tong)(tong)過(guo)增(zeng)強(qiang)Wnt信號的(de)傳導(dao)，促(cu)進細胞(bao)增(zeng)殖、干性維持和組織再生(sheng)(sheng)(sheng)，尤(you)其(qi)(qi)在(zai)干細胞(bao)培養(yang)中具有(you)重要應用(yong)。在(zai)干細胞(bao)培養(yang)中，與(yu)Wnt3a聯合使(shi)用(yong)可(ke)(ke)促(cu)進自我更(geng)新，抑制分化。該產(chan)(chan)品表(biao)達系統為CHO，通(tong)(tong)過(guo)SDS-PAGE測定(ding)純度≥95%，內毒素(su)通(tong)(tong)過(guo)LAL方法測定(ding)≤10EU/mg。通(tong)(tong)過(guo)其(qi)(qi)在(zai)50ng/ml Wnt3a存在(zai)的(de)條(tiao)件下(xia)，通(tong)(tong)過(guo)CHO細胞(bao)產(chan)(chan)生(sheng)(sheng)(sheng)Topflash報(bao)告基因(yin)(yin)活性的(de)能力測定(ding)其(qi)(qi)生(sheng)(sheng)(sheng)物(wu)活性，預(yu)期(qi)ED50＜1.0μg/ml。河南VEGF生(sheng)(sheng)(sheng)長因(yin)(yin)子有(you)什么作用(yong)

北京科(ke)昕(xin)(xin)生物(wu)科(ke)技有(you)限公司(si)匯集了大量(liang)的優秀人(ren)才，集企(qi)業奇思，創(chuang)經濟(ji)奇跡(ji)，一(yi)(yi)群有(you)夢想(xiang)有(you)朝氣的團隊不斷(duan)在前進(jin)的道路上開(kai)創(chuang)新(xin)(xin)天地，繪畫新(xin)(xin)藍圖，在北京市(shi)等地區的化工中始(shi)終保持良好(hao)(hao)的信(xin)譽(yu)，信(xin)奉(feng)著“爭取(qu)每一(yi)(yi)個客戶不容易(yi)，失(shi)去每一(yi)(yi)個用戶很簡單”的理(li)念(nian)，市(shi)場是企(qi)業的方向，質量(liang)是企(qi)業的生命，在公司(si)有(you)效方針的領導(dao)下，全(quan)體上下，團結一(yi)(yi)致，共同進(jin)退，齊心協力把各方面(mian)工作(zuo)做得(de)更好(hao)(hao)，努力開(kai)創(chuang)工作(zuo)的新(xin)(xin)局面(mian)，公司(si)的新(xin)(xin)高度，未來北京科(ke)昕(xin)(xin)生物(wu)科(ke)技供應和您一(yi)(yi)起(qi)奔向更美好(hao)(hao)的未來，即使(shi)現在有(you)一(yi)(yi)點小小的成績，也不足以驕(jiao)傲，過去的種種都已成為(wei)昨日我(wo)們只有(you)總(zong)結經驗，才能繼續(xu)上路，讓我(wo)們一(yi)(yi)起(qi)點燃新(xin)(xin)的希望(wang)，放飛新(xin)(xin)的夢想(xiang)！